	   SnapGene      hAAGCTTGCATGCCTGCAGGTCGACTCTAGAGGATCCCCGGGATTGGCCAAAGGACCCAAAGgtatgtttcgCTCGAGATGGCTTCTTCTGAAAATGTTATTACTGAATTCATGAGATTCAAAGTTAGAATGGAAGGAACTGTTAATGGACATGAATTCGAAATTGAAGGAGAAGGAGAAGGAAGACCATATGAAGGACATAATACTGTTAAACTTAAAGTTACTAAAGGAGGACCACTTCCATTCGCTTGGGATATTCTTTCTCCACAATTCCAATATGGATCTAAAGTTTATGTTAAACATCCAGCTGATATTCCAGATTATAAAAAACTTTCTTTCCCAGAAGGATTCAAATGGGAAAGAGTTATGAATTTCGAAGATGGAGGAGTTGCTACTGTTACTCAAGATTCTTCTCTTCAAGATGGATGTTTCATTTATAAAGTTAAATTCATTGGAGTTAATTTCCCATCTGATGGACCAGTTATGCAAAAAAAAACTATGGGATGGGAAGCTTCTACTGAAAGACTTTATCCAAGAGATGGAGTTCTTAAAGGAGAAACTCATAAAGCTCTTAAACTTAAAGATGGAGGACATTATCTTGTTGAATTCAAATCTATTTATATGGCTAAAAAACCAGTTCAACTTCCAGGATATTATTATGTTGATGCTAAACTTGATATTACTTCTCATAATGAAGATTATACTATTGTTGAACAATATGAAAGAACTGAAGGAAGACATCATCTTTTCCTTTAAGCGGCCGCcatacatatttaaattttcagGTGCTGAAGTCAAGTTTGAAGGTGATACCCTTGTTAATAGAATCGAGTTAAAAGGTATTGATTTTAAAGAAGATGGAAACATTCTTGGACACAAATTGGAATACAACTATAACTCACACAATGTATACATCATGGCAGACAAACAAAAGAATGGAATCAAAGTTgtaagtttaaacatgattttactaactaactaatctgatttaaattttcagAACTTCAAAATTAGACACAACATTGAAGATGGAAGCGTTCAACTAGCAGACCATTATCAACAAAATACTCCAATTGGCGATGGCCCTGTCCTTTTACCAGACAACCATTACCTGTCCACACAATCTGCCCTTTCGAAAGATCCCAACGAAAAGAGAGACCACATGGTCCTTCTTGAGTTTGTAACAGCTGCTGGGATTACACATGGCATGGATGAACTATACAAATAGCATTCGTAGAATTCCAACTGAGCGCCGGTCGCTACCATTACCAACTTGTCTGGTGTCAAAAATAATAGGGGCCGCTGTCATCAGAgtaagtttaaactgagttctactaactaacgagtaatatttaaattttcagCATCTCGCGCCCGTGCCTCTGACTTCTAAGTCCAATTACTCTTCAACATCCCTACATGCTCTTTCTCCCTGTGCTCCCACCCCCTATTTTTGTTATTATCAAAAAACTTCTCTTAATTTCTTTGTTTTTTAGCTTCTTTTAAGTCACCTCTAACAATGAAATTGTGTAGATTCAAAAATAGAATTAATTCGTAATAAAAAGTCGAAAAAAATTGTGCTCCCTCCCCCCATTAATAATAATTCTATCCCAAAATCTACACAATGTTCTGTGTACACTTCTTATGTTTTTTACTTCTGATAAATTTTTTTGAAACATCATAGAAAAAACCGCACACAAAATACCTTATCATATGTTACGTTTCAGTTTATGACCGCAATTTTTATTTCTTCGCACGTCTGGGCCTCTCATGACGTCAAATCATGCTCATCGTGAAAAAGTTTTGGAGTATTTTTGGAATTTTTCAATCAAGTGAAAGTTTATGAAATTAATTTTCCTGCTTTTGCTTTTTGGGGTTTCCCCTATTGTTTGTCAAGATTTCGAGGACGGCGTTTTTCTTGCTAAAATCACAAGTATTGATGAGCACGATGCAAGAAAGATCGGAAGAAGGTTTGGGTTTGAGGCTCAGTGGAAGGTGAGTAGAAGTTGATAATTTGAAAGTGGAGTAGTGTCTATGGGGTTTTTGCCTTAAATGACAGAATACATTCCCAATATACCAAACATAACTGTTTCCTACTAGTCGGCCGTACGGGCCCTTTCGTCTCGCGCGTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGGCCTTAAGGGCCTCGTGATACGCCTATTTTTATAGGTTAATGTCATGATAATAATGGTTTCTTAGACGTCAGGTGGCACTTTTCGGGGAAATGTGCGCGGAACCCCTATTTGTTTATTTTTCTAAATACATTCAAATATGTATCCGCTCATGAGACAATAACCCTGATAAATGCTTCAATAATATTGAAAAAGGAAGAGTATGAGTATTCAACATTTCCGTGTCGCCCTTATTCCCTTTTTTGCGGCATTTTGCCTTCCTGTTTTTGCTCACCCAGAAACGCTGGTGAAAGTAAAAGATGCTGAAGATCAGTTGGGTGCACGAGTGGGTTACATCGAACTGGATCTCAACAGCGGTAAGATCCTTGAGAGTTTTCGCCCCGAAGAACGTTTTCCAATGATGAGCACTTTTAAAGTTCTGCTATGTGGCGCGGTATTATCCCGTATTGACGCCGGGCAAGAGCAACTCGGTCGCCGCATACACTATTCTCAGAATGACTTGGTTGAGTACTCACCAGTCACAGAAAAGCATCTTACGGATGGCATGACAGTAAGAGAATTATGCAGTGCTGCCATAACCATGAGTGATAACACTGCGGCCAACTTACTTCTGACAACGATCGGAGGACCGAAGGAGCTAACCGCTTTTTTGCACAACATGGGGGATCATGTAACTCGCCTTGATCGTTGGGAACCGGAGCTGAATGAAGCCATACCAAACGACGAGCGTGACACCACGATGCCTGTAGCAATGGCAACAACGTTGCGCAAACTATTAACTGGCGAACTACTTACTCTAGCTTCCCGGCAACAATTAATAGACTGGATGGAGGCGGATAAAGTTGCAGGACCACTTCTGCGCTCGGCCCTTCCGGCTGGCTGGTTTATTGCTGATAAATCTGGAGCCGGTGAGCGTGGGTCTCGCGGTATCATTGCAGCACTGGGGCCAGATGGTAAGCCCTCCCGTATCGTAGTTATCTACACGACGGGGAGTCAGGCAACTATGGATGAACGAAATAGACAGATCGCTGAGATAGGTGCCTCACTGATTAAGCATTGGTAACTGTCAGACCAAGTTTACTCATATATACTTTAGATTGATTTAAAACTTCATTTTTAATTTAAAAGGATCTAGGTGAAGATCCTTTTTGATAATCTCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCATTGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTTGAGTGAGCTGATACCGCTCGCCGCAGCCGAACGACCGAGCGCAGCGAGTCAGTGAGCGAGGAAGCGGAAGAGCGCCCAATACGCAAACCGCCTCTCCCCGCGCGTTGGCCGATTCATTAATGCAGCTGGCACGACAGGTTTCCCGACTGGAAAGCGGGCAGTGAGCGCAACGCAATTAATGTGAGTTAGCTCACTCATTAGGCACCCCAGGCTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTgtaagtttaaacatgatcttactaactaactattctcatttaaattttcagAGCTTAAAAATGGCTGAAATCACTCACAACGATGGATACGCTAACAACTTGGAAATGAAAT  *Ñ                                                   
               %                     	                     
   
                  "   
                                                                        	                         
                  "         $   9   &            #            (                                     "                                                                         
         "                     
                           $                                                (            "   F   &         $         
                                                         
      	      
      
   	                                                                                                            	      	   	                     
                           OóÎŒ	ÊËäHIJîï?@A & ù bóø§��	Ìç©ãð Pµô½Çq
}
ÊKË à=±Ï?	ü
å?B^ § ­ ã |Ä'Hå{ž"	¤¯îr»cªÖäF ‚ † ³ cùÛZq¨©ÅŽ	š	ø	èÐñOþW¹×\  ' ú X¦ô‡¨¸–Œ
OÍnx#�ÿU-­ÅK 3 ’ Â æ ÙKfo§…´ $þÉU^¾È		S
r
ÁB¤F < E™
æ
ÓîXs¹Àû Q°¶õZ	o	~
+§ILmK  ‹å�Ë;Ì 2s²Ä4	á
Cuþ3±C •³á‚	,
ý
S'\ÇB_‹ O n½ÐÔŸ£zñ@”©5 , õ8á5>7	@	‹–æ°bt-
  ä }Im»¥sáü J p ¨ ® (�|ö#	Ï	¥
`<	{’«× h€Å<•->Ìæøü	
y
§
/|ÒÃðy Þ”ŸèÈ
°ï
¼Äâ\„d‹Ùå$GÇçøeÁ) ƒ ¤ ª ° ´ ¿ Uvú´ØÜ!Tÿª­ÆÑù	f
´
¬ø§p¦ÿ% Y ž d*Ï[mzð‡’)3¡ßa	%	�	ò	K
V
A+ó”­òPXØ9]b h ~ ˜ oZ7r¤©Ó	"bôº ‡ ÆÓæ¼›	‡
·
éF'¾DhvÑß L y£§ÖõE–W5¹‘šX—	`
Å
Poë$4H û 4ˆ¢'z×H	f	Ý	€y²>´‹#.}®ÌÆL ( r =Y”·KÂØ©ûgíM}�+¥1é  q¥i
�
ž
 Îà5žªø V	 ëp[~x	ö
  “ Ã Lßg™ôJk¤Ñ	Xš1µG  
g&jS 4 · ç ÚƒÃ¨†c¿êlãã Ãã€	{
ß
ÈGïü«· %ÿ'ÊV_
	F	T
~Â¥Ð‰2Åöcw¿ ÿö^ë¿É	
¡	µ
 _™(ú”	s
lCQ
 ÐøÎè ð£©Å ´› @�	Z
š
\ÔïYtÁ÷ = FŠŒÃ	þ	
ç
ñ
Ôûºüµ® `9ñ1 ‚W“Ã±ÔÁn
,ä0*² _ z Œ Î Ú %j‹¸Çß0>®²[	
¬è'›{" A ª¸—$Îm·½-R^v±·ö'Pp	§	<
©
»
¨iÔJNLû
 {/YÕ
ÚMn�  æ2Ë
<Í( áîb‚­·a	{	;_æ;ò úÜíGŒÌ >XŒp˜ ó”»Åß	5	˜	*
—
ä
‰vÑD9²ÅD`\Ã 3Dÿfîú 	tNµ	Æä‡&™( àYL³–	â
3�†4˜Ûé
&g  –r¡êi‚Ü�ˆ6ÈÙë<` äÇ�þ
"(5]+[in  ´ÊRâ.	-
FTS� ›Ø–ü	ƒ	u
Ê
ÁßÈSÝCŒ 1¡¤ÑP
c
nñ ¤¯9$òõA|É?ô6 …o™éÚ
²=^ßÞQ  P õ ýÖBHˆÕä	¹U'{_Ÿç•£+ F 6Œ›*ø¾uÉ	B
’Ú7‡Òª öâ6šù
¾R¦ÖÜ. - ùqŒûç±øšWï 
 aâü8	A	M	4
ÛEÍ÷Icu€½ 9e[?©
¯
—óZ °>	¨Êâí>  2 … ¦ ¬ ² Á â å W~&J†Ún!	÷	¦®„œþÕýÖ  ; #D¯ÈY	~	A£r¸J	 ¼3	t¯2°Š“  g~€ç÷û	¦
_[ƒØ( } © ¯ T)Ò6S£åÒ‘ ¬Ð$	J
¶
!@aò½“¬ K q <x“¢D¶Vpúf¤ì	_
h
�
ê4=|©÷
Š| ¶ 	Þ˜óI‚}£w	Ð	i0bé &Ââêùz
k} îûÄõb ?‹Íçý	
Y
0[  y Ù i�·ÆÞz=°·–#.¼,Óm
¨
Ô
~hÓ«&zú
 oà1:ñ òß“º–
ÅãC…8e†—ÄÚ%èíù	[fÂ ÉQ• éÉ
E!ÞR€ÇŒZ  0ü5 Õt‡±ðT]^æÈ>~Ýó* ¨ú½ò¥YHÛ 1 : „ ¥ « ± À á V%Ù"C®Ç 	=	ö	­›ýq1§¯" µ fw’¡CµÑÝRU¢ o}eŸ£«ú	^
g
œ
µ
 ^¨öZ¼ x Ø ¶¯¶"nß%+ŠÒáX
Ó
}gù   û4ñ’§DùñQ–Ã Zò$ 0 9 w × à eµ$3BÐBQ¡®n|*¢àõ	W
]
Ò
C|šõü•®Y9 Z CDEæçèéêërstA í${·¸¹  !"K“”•¡‚b&	ó	ô	\
B†™Ãô1234QR/0& [ Ÿ ^»`lÝî%ÅIñ#L}¢ñ4ƒ	'	�	³	½	à	µ,Ä‘ 1:^c Ñ (Fì+<uœ\œ¼(ºˆ–cL
7‡-5óSÙÿ \  � _±‡¥íV^	l	‘	á	Â
#õ$9t2_ È Ê3s&Æ
B:=£
	(	i	´	¾	Ô	é	ì	f-’# i ™   p¼Ê[mÞï.ÔJtÅò$@~É59Úcb”p»Ì! a8ªÓ`Mò!„¶·Åâ; w;M
¸
�-(ÍEiôT]àkE )Ç]�½ù!�ê‰

“
ƒÅ*_.ÒÉÚ T( ˆ Ò Gí,=�Ôx~ËÏç½Úõ)7»#Ùˆ
�Ö8?G[ˆdv¿wW vM—dœ	×	vµê6±  M € � `z¤×ñöFlX“¦6‰±¶ñm	QÈ%pì!M3I n – ½ m²ÍÀºîÁé1’Yd	Í	 
Ã
Æ
$Vzö%½áç` ? ] #¨‘ˆWk°_	’	Á	Ý
Ò�u°  â—Šö›p˜Ý		â	a
g5:¡ 4Ç�W	g.?$ Æ A³1¯|;>{Ø!g	j	Õ	Þ	ê	t�z³µ/¯Ç » ü 5j‰£Ë C®	¿	í	qs É »ü(tŒ'Á¤	)	I	µ	þuŒ“Ó~ÍM ) ¡ ÁÀHnü/ó%[Žîï	ó
¬ÙU~�¼ b >O‹Ž¥¸ðQªïu±	76é
d<cN·6q‡ê" q¯ËfLÃÙßEK¨ÆÊÐ:hÛQ	£	«	
/
‚Ž•,Í" j s š ñ þ 7Z•½\`ÌÕüA¹	

¦2 9ü¦„
¡áý6 â�«´Œ«ó"…ä0	j
ÏÖùW< ÒRbåÔaTNŽ
H·Ÿ¸ þ   ,r‚FÅ	Ÿ
ì
«Æã¼ž q;\MFk x<˜w
ž)!jßáEF µÚìy	¹
.Î K	N
÷
�õU^líO ž…	”
>Y2W„¶ÓHÔÛ 	Èjv…šž÷"K^ÃëTŸˆ¥Ò	›Ã+`/ÊCU ” Ä *Màþ^Ž¾ú‡¯€ˆŠn·	
‚
ÆÑ‹ hƒõ\­Rb�l„
UqšÒ e ‰ Ë ˆÕÛ*$ó‰
†@káJ\ßw•xT Ý î½yÈÌÐ¾48.Ú9H Ó ë H>€ž¨èöh¼dt…	Ì
'�”KŠw‰· œX  Ž-)x3×OmeÀƒ? ˜Ä	+	©¶ë:Ê*s²ºÏä ¸ è ÛwFN„ìòþ7w ‡dÀ7@aŽ´ëä Tä¦eÕm€ 5 *¡�	Ø	F
ëŽ ø aò÷¦ßN´òp
|
ÉæÉã  � ‘ {¥ÃØGYep§·Ää‹
mqº"bN¬V¸J[
 Šýn	R
*¦íWHú + N m”17²ÃÓ�	à
R&B¢yðýs~,A4 o ”Ý,“ºËõÎ	
¤
Ç
.{Ã;ÑázŠ‘#ÂÆ÷dxÀ" X g — £ ¾ nY³ÅÎ× þ»ï† (2Þ`	ñ	U
e
ó÷&¦C8a 3Õ•¡&JÁ×y�ÖWG	e	Ü	Ä
ß±L€³3¤Ëè fÂêZjõ
%W™¾â ˜õ']		“	Þ
1ªv´¶¾ ‰³š÷_�ðÂ	Ó¢Äö @ ^ ‹ Í $Š©V’Â/­ÍXl±]&À¦	;
MçŽ± =Wù aì‹Ê`	
^—

 Þ		•	)
ˆ2�˜   ãœqût
hÀ�Û*R; „˜£‹š)÷AG~ã	A
b
Ù
m®#&Þô6{†¢ 	 d`û™3
pDQ÷ X	@¢®‰  | 5òÑù�Ïv	h/{ñ é0Ÿª% ÈÔ S¤Æ} ðµ!mÞ‘	<	›
]ðP0Âø$ Ð Ö ß 'B´º#2;Aq›@P»Ü'H|� ²	ß	[
Ñ
{´…˜þ. Ž Ç É°2Ò	AÄ9<?8Ù]	h	k	ë	e“¶á8s }ÊÎœ6:é"ØÖ	u‚´Õ>ZÌu°ÈS > ¼ "láðk�Ìj¯À0ðÜ	À	ÿ	Ü
f L ¯à @²iº{‹ÀV	rt a ý 6eŠ�¤¿GD§°ÏZ�P	¢	ª	î	

è
ò
;«¶ Q³EªÄ	ë
Õü»ý� ´:J	LjìN ýu�¬Â‡Qa¶	�
	Ðpƒ™ d Ê Ü ‡�§¼Ç(3ws-ò2“JNlv”
 )ESëñ¥	*	ÿ?`�Ôê)¹Î * ÷ Âdo0
M³Âo
)åVa+Z ¢ X” ÄIý“…�¹ÕÝð	£
ô
-Þ²�"Á UÁ.²™ø¬Ìô&\`Šï¥	L0³½  ƒF}ú(
2
@
¿1€­Ú)Pz… { ñÓu	z­|ˆ( � Ï Õ &¹È":@ï1?OºÛ&GÃÝ
87ÿ×;	\	Ð
=dO„’—Ë7rý- ` !?k±àPhŒ�¹¯²i©¿Î/U	©	
ê
eªœŸ c Û Œ¦ÆDR«ðvr³€
K’Mké(i¸˜ë	 ˜«Ë„	EL_²¸Üù¤	'
1
?
¾±KO/y„À"  °gîN¹ÅÚC%FÒÜq¾Í.T	¨	Ï
©jyƒ‘–h—žüF è	MÄàBL©ªÏÐÑÛnop€�‚ƒËÌ;DJKwx÷øR	S	‡	¬	­	$
%
&
0
=
>
ª
¼
Î
»¼½��¯°Õij-.fgxƒ#& B JNr«Ìé
áiM�Ç¸Ñ<Siy(CQq	ˆ	®	
«
½
Ök“MÎ$ C › ò sjÍÕjDR‰	¬
×N k t [ž¬¾]|âêN|ý¹º	æ	
‹}¹3Ï%$ R U ÿ K–™ÿªa�0j‘¾ÈØBZfvÒzr	¯	Ö
–Œœ�§ í 8OÍ‚êÖ=T)

7
¾
W›Ûl¡éo”N¥ §3SÌŠ		¢”=Î
  H œ t:kk…
) ÎýED	âþØO9¬ D ó çWÖJ
­
ÙÏ7ØÔ ãOºÀ®¸å1	|	k
`ç~<ó& u \�Ÿ^}¬ë}µþï#c»	ç	
‘
úXº l ­¿/­ã‘�¬çôúb	Ë	Ð×oŒ»4… �â†ƒD
5<H‰�Ð=A V ÓÕbûd[wÝh�×
—�¸!ÂÜ¨   c1kçCOî°	Q � S  L—œ 8Sæb‘zŽÁÉÙgÓ{s	Igÿ‘ š«U’¿åH�
Í¹ Æ	
œm½¦ î -9ƒ+Y×q¿
Üê ë?�>*8
 
¬™äp• ! PÎsƒ”�,0GUw 
í
X÷Ç¢Ÿ!O % <œ¼ÆÍ‹	û
>G] ¨z•™	N£íwT,³ÏEÄ äT]€	˜
å

ÀÒE:¿l ôr4à6	+
Š[•žÆa¨
 I ;=lx
	àæïû � uly†
³
«E*ogu¥Þ	 4™Ÿ "*0G  kâFR
 ^þE	
ÇÏPˆ Ï8	ð
úÿï¨´­
 
¶uOº
ã/Ùš)	 ÛíF¬¶z	å': XKM´—	ã
Ð_%' šÆ×	-	4‡5ÜØêhm E ô èÈ	O
¸‘8<ÙžÑP øáZL	
®
ø
ÚÌ™öV¼Õî  …¯2	}	ƒ·ÉÔì=I’Õ ;S—äH¢æë	I
 ?é3aè‚‰' Ýy»Ál
9Zjíúôa /ŸPs†¹•
ÝB7X]…YÚì=Ü ‘ $d‰ž¦ÿ
fY»ñ / 8 v ]å_k›Ÿ­ì#Ä¶ÿJ ð¼	6Âû,0� 
É†-_sìUÈ Ó	è	Á
#aoË ~wø LvÙô~	
’
ŽœÄ),^c\jDV  m • ’¿ˆ°µ‰èõoc	Ì	UyÇÑ¼Œæ º Å 0®ûÿŽ­  	sýpÒ ð ®ÀN_ûPËî6¸	
.
ØT�Ž5† +Ñáä�S�‹ûã/	ƒ
G Ù—v
œÞD i‚„ö[]†®Sœž‡m„	=ÂTVŠÑÓB ê c„	Ë
…‰àIÞ¶‚›>  ãýE
69³Ér� ¥üÞÒQ
Š
Al¡¥¹âxùr}@U W f 2ÔÖÖÜ+exiôÛ	d
˜ò°:KàBy£Ê7 Š Ì ‰<V—\%Ž:
]–Ãæ
©õ  c¢@Ø
o‡Ž"%Ýóö—  /R¡ž Þ pšÉÍÑ59lè€±	³àR ïd¾z¿¦DYïÛO	¡	Û
:Kß †ê2†P,I>_Ïo‚  ö TŸ-c’÷|‰¢
(Ý(`!Y Ô !9?Âh¨þÖ:	t	
J‘LÊ, IMçíAh�ÊÚCIB†	#
Í
ºx®h ew‚’¿–� Q T ì ˜�þ�©é�i{½×euÔå	6
•V‹šŠ|›¸ è¤ G VIC	Ø“Î×8Ó« �.¬€æù¿Ê	C
�
4Gnºˆ€„@  ›7cy�ÀæägPfÁÛ	 *“œ+/vö  $ ãy›ú
ìZ�¿S+¾§	 ²
ªnt¤Ýå/Q	 ]7«
ï
ùî§³ ÷™Å	,	Ç	·;Ë»Ð×$ .:RÜx„GH
8èAìù\ëX‘ . 7 ,uØórIÀ
�eÁb�ð ¹ ï ÐúOí5ÿrxüå é Z…ŸˆÝ8²µ›  ;U–?Ú	9
åø	q–¢
 …¥X+N	 	În�J ì,@gŽ§ýA9	
"
5
¡
Ü™­Éšdv�¾ bå.ãfB	õFÖ # \xª±
î
Yøí£#P 6 QÏtž4HG
[� +:f„•¤-W@Ÿ	Ù	
!
˜ôÈ¡ " ¢£123Vž	°
ì "�  &ü  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   	                                                                     	                                                                                                                                                                               
                                                            
                                                :   K         #      
   (   1   
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             	                           	                                                               
                    
                : K   #  
 ( 1 
  Zë  [o  [ƒ  [�  ]ã  `�  dWƒg¤Ð# ¹ Ðìx§¾dv$Ÿí	·
'3x868	—s
üàR6ü8	—WÉ`Œï ëÞëÄë
sBm‡
Ò57	óV¸$û ÙE2 =>	¥ f
§ ƒwƒ2 ?±ëx	 Š2 0B‹Ç	ÐÁ¸
-+ ô4Š,h ˜ o»ZÝÓI} Öd
|ëx	ö
:	‹.Ù™(”ús
È
Qús
Q# G =	76c6q› sj=ús
Q+  =v
ÞC	´ Ü Ã	ºKá Ã‚ß—	 3 =š	è»äBFm‹¹’¢
!�ŸË�" # ë�Êë*½"Øâ¾}ô4[¤ôä4
Ÿ:â8F|™(”=ús
È
Q_l çb	Ë	»‹Š›yù	  
 Ñ 'W|Ò?\ ˆn‹ pŒ
�
�©ÿ
3i`…# N¹Ú%FÏ
ƒ–üu±CÖd
¹|¢"óh ˜ ZÓº ­ 	   û ŠX^`ús
iQ H l 9�Ÿ‘çýcD	b	Ë	¸»Xº¢O-×Í/Ÿ¹•
B7=“G  /Ÿ= G �’:	¢
!Bì	¨ãE
	p
_ð0um  Œ
Í�ÿU qž
ª„ëøq‘GÌ�|Ï	¡rnÜ$òõ6Ùë<3 æ Ù8‹à=>?	§…–å# $ x›ú
Y$ÉU^S
Á¤âD
53 æ Ù‹§…rÜ6Ùë<¡n$òõÐL y£ÖõEW5PoëHq6¦óö¡rß5	*
n‰Ü$òõ6Å`ÖÙë<# $ „x›ú
Yëøq‘Râ.	F–š—	`
4‰
@káwTÜx8ìù¦ô¸–On#+�¿Ü+ô:ày‰ Ë ˆ$\Y\•k²Ü+l¿ôt	:àyÁjíúôa…àIÞö
µä&#»Å\ r Y”7©û¥ð1'V ÓÕãdw§hå—¢`çmÎ&Ž5
™šƒ ¤ ª ° ¿ UØ!­Æ¬p¦Ú ‹›á²‚
;ÔYtè'´ v´ÜTÿªù	f
´
§S —œzÓð á‚;r Y”7©û¥1óöß5	*
‰Å`ÖÁj…àIÞíúôa– ½ m²Íºî1ö%`k ¬¾‹3M
XKM´—	ã
Ð_%'÷™Å	,	Ç	·;Ë»Ð×$ó”»Åß	5	˜	*
—
ä
‰vÑD9²ÅD`\Ã`9ñ1 0ü5 Õt‡±ðT]^æÈ>~Ýó*àYL³–	â
3�†4˜Ûé
&g /R¡ž q¥i
�
ž
 Îà5žªø V, õ8á5>7	@	‹–æ°bt-$ ãy›ú
ìZ�¿S+¾§ m • ’¿ˆ°µ‰èõoc	Ì	UyÇÑ¼Œæ , O 0ü5nõ8 Õá½5>t‡¨ÐÔ7	@	‹±ðúT–Ÿ£½æò]z¥°ñ@Y^æHbtÈÛ->~”©Ýó*5 > m • º ¼ Å "@l²áð0ik�®ºÌûÿ{‹’¿ˆ°µÀ‰jŽ­¯Àèõ0ð oÜ 		V	c	À	Ì	ÿ	Ü
UfsyÇÑý prt¼ÒLŒ ¯àæµÚìy	¹
.Î  ãœqût
hÀ�Û*R;i ™   p¼Ê[mÞï.ÔJtÅò$@~É59Úcb”p»Ì!bå.ãfB	õFÖ ä }Im»¥sáü� Ï Õ &¹È":@ï1?OºÛ&GÃÝ
87ÿ×;	\	Ð
=dO„’—Ë7rý-  ; 0ü5#DT Õä¦µÚì¯Èet‡Y	y	~	¹
±ð.TA£Î]rÕ^m€¸æÈ>J~Ýó* H œ t:kk…
)  ã     Ô  h        hS£cãBÇ¹oðTÕ	Š³±:ë…X¦ž¶­R‘`P^)`v±ZA}˜PvYâ•éRžT}ëÚÎ€fº»ÝkÖ`nT©ŠWoN¯F™Uzº¿Eµ`˜Z±FŽx§µëºÔ`b­©•)ZÚ¥«öá�ô¦5UW˜N¹áQêoQºT^ÙSºW¥F¦è¡kVæ¦`åUô­zô¦˜¡ŽW¡šzí–ižh¡u˜T^vÛªú”ÃÏÙÙ©Z­áKR¡BþŠYÄ¥Pš¥EÚèÕ Y×™{wX™Û`ÑÕÕE�mR‰J•Øjž^^[†¥j´^µZGuÚ`S+^MiµÕg½h1ƒø¾©ôuöŸ‹ÝÖãú±Q¿\Uvë¡*%ÓŽ§v�…æudÚÉ½xLð³Ÿiõè¸"ÕYdÎ-´IJ•á+ž^\If¥j´Û³?#î¹KÖžë]¿�Žêïâ;÷ÿš¨¦›U^»¥«¨ª¤ëªRß¹u…h‰ÕY–²YU,UVˆïïÿie–¹¿U¹Ýb¸‰Þºbªž¸ejªÛdU_7uYúm˜§*Ò¦5ªšºÍË€û¶µmŽÛ!U*�&ªªµµ!R¦¥ªøêŽª «þh¨µ±ªº9VÝI¡„ÜcQQ°QB *í P„‘Jj I"æ ª�¥aÑgkõ™õv^*ùä°òp?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC¥ì†sæªd)bØe–
ºG-7ªÀˆÌþj*j®Vvµf&ó¶Ö_á•Žµ–hUAD˜I­v¯"Ïé¯ê¨Ãj�¯Š¨íýÎT•F8Q´ #q )Û�»]0”o¡«?Å*½a„Þ©R¸æ Ì&›òhsÀÔM{<ÙÞk´Xz
{}-ÑTÛ§‡IDZcHãÙ}„†]ã^ž¸uÆÁÅåóª£uØ m‰{>†Ê|……=ŸWL‡}Æ>$ÖuÊ3Wš^^z{“¯Ã]idxÁ•(Ð}ëŒì?¯
š8enð„È³	¶�7€=%?¿&É)¹Üp´5æ‘Ñ³„d#íá¥6‚^-R§¶fz‘¡©W­ª–¥PnBoª†[¶U¿¥ÈJ¬¯xL´ÉFÕë¡êªã2[Ž:5uU}óŸL ¨¨ðmDç×º«Å	x:ÓDÍõg‹ë’$òJCßzÔ^âMóçgìî9oŠ} ã�H1”².Ÿ�íG)ðeÓ…À²7tý:ÅÇç|^Ÿ�2hEL÷:üPPÁÐ›ÂSÁt3q:ô W>	º™/‹¬÷î„Ë¨†;- æW=5Ì>ªp¯ƒêŽª;v+«ã)¿á® eòióê†|ìóO4Ä´„ÄÁDÏÖsWÏ»üÌ ñ­¥�87
¿L!3\Ö–!);{iÿC©Þ¦:ðì˜¢ Z!0eÖ­Ýtæa§=N%*Waºyyy®Ú•ªÑ:U`á[{uÆs—^�XV   =   F  û    µ  ç  !  S  ø  *  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ü<?xml version="1.0"?><Features nextValidID="9"><Feature recentID="8" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4567-4583" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4543-4559" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4469-4490" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4505-4510" color="#ffffff" type="standard"/><Segment range="4511-4528" color="#ffffff" type="standard"/><Segment name="-10" range="4529-4535" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2457-2561" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3593-4181" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2630" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2562-2630" color="#ccffcc" type="standard" translated="1"/><Segment range="2631-3422" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="1" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#ffff99" type="standard"/></Feature><Feature recentID="0" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="78-755" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="1:4:46">2021.7.7</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  á     Ò  `        `S£cãBÇ¹oðTÕ	Š³±:ë…X¦ž¶­R‘`P^)`v±ZA}˜PvYâ•éRžT}ëÚÎ€fº»ÝkÖ`nT©ŠWoN¯F™Uzº¿Eµ`˜Z±FŽx§µëºÔ`b­©•)ZÚ¥«öá�ô¦5UW˜N¹áQêoQºT^ÙSºW¥F¦è¡kVæ¦`åUô­zô¦˜¡ŽW¡šzí–ižh¡u˜T^vÛªú—ÙÙ©Z­áKR¡BþŠYÄ¥Pš¥EÚèÕ Y×™{wX™Û`ÑÕÕE�mR‰J•Øjž^^[†¥j´^µZGuÚ`S+^MiµÕg½h1ƒø¾©ôuöŸ‹ÝÖãú±Q¿\Uvë¡*%ÓŽ§v�…æudÚÉ½xLð³Ÿiõè¸"ÕYdÎ-´IJ•á+ž^\If¥j´Û³?#î¹KÖžë]¿�Žêïâ;÷ÿš¨¦›U^»¥«¨ª¤ëªRß¹u…h‰ÕY–²YU,UVˆïïÿie–¹¿U¹Ýb¸‰Þºbªž¸ejªÛdU_7uYúm˜§*Ò¦5ªšºÍË€û¶µmŽÛ!U*�&ªªµµ!R¦¥ªøêŽª «þh¨µ±ªº9VÝI¡„ÜcQQ°QB *í P„‘Jj I"æ ª�¥aÑgkõ™õv^*ùä°òp?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC¥ì†sæªd)bØe–
ºG-7ªÀˆÌþj*j®Vvµf&ó¶Ö_á•Žµ–hUAD˜I­v¯"Ïé¯ê¨Ãj�¯Š¨íýÎT•F8Q´ #q )Û�»]0”o¡«?Å*½a„Þ©R¸æ Ì&›òhsÀÔM{<ÙÞk´Xz
{}-ÑTÛ§‡IDZcHãÙ}„†]ã^ž¸uÆÁÅåóª£uØ m‰{>†Ê|……=ŸWL‡}Æ>$ÖuÊ3Wš^^z{“¯Ã]idxÁ•(Ð}ëŒì?¯
š8enð„È³	¶�7€=%?¿&É)¹Üp´5æ‘Ñ³„d#íá¥6‚^-R§¶fz‘¡©W­ª–¥PnBoª†[¶U¿¥ÈJ¬¯xL´ÉFÕë¡êªã2[Ž:5uU}óŸL ¨¨ðmDç×º«Å	x:ÓDÍõg‹ë’$òJCßzÔ^âMóçgìî9oŠ} ã�H1”².Ÿ�íG)ðeÓ…À²7tý:ÅÇç|^Ÿ�2hEL÷:üPPÁÐ›ÂSÁt3q:ô W>	º™/‹¬÷î„Ë¨†;- æW=5Ì>ªp¯ƒêŽª;v+«ã)¿á® eòióê†|ìóO4Ä´„ÄÁDÏÖsWÏ»üÌ ñ­¥�87
¿L!3\Ö–!);{iÿC©Þ¦:ðì˜¢ Z!0eÖ­Ýtæa§=N%*Waºyyy®Ú•ªÑ:U`á[{uÆs—^�XV   =   F  ó    ­  ß    K  ð  "  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ü<?xml version="1.0"?><Features nextValidID="9"><Feature recentID="8" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4559-4575" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4535-4551" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4461-4482" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4497-4502" color="#ffffff" type="standard"/><Segment range="4503-4520" color="#ffffff" type="standard"/><Segment name="-10" range="4521-4527" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2449-2553" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3585-4173" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2622" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2554-2622" color="#ccffcc" type="standard" translated="1"/><Segment range="2623-3414" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="1" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#ffff99" type="standard"/></Feature><Feature recentID="0" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="78-755" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="1:4:35">2021.7.7</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  à     Ñ  Z        ZS£cãBÇ¹oðTÕ	Š±ƒ®¸UŠiákaÕ)â–ak¡AAGÙ…ež)^•)åAÞ½¬èk«½Ö½fåJ˜¥vôášôi•W««ôPkVQ)…«`A(çŠ{Q®»­F*Ú™R•­ JZ¿nJcUUy€`ëž¦õ�+¥Aí•;¥zT`AÚnŠµnjfU_J×¯AšiŠåz§®ÙaF™æŠY…EáAGmº¯©}�š•ªÐŽµ*!Ÿè¥‘lJU	¡ªTQ�]®�ÝZ�y—·u‰�¶]TXÕ(”©]†©ååå¸jV«EëU¤w]¡F2µäÑö›]V{Öƒ?‹êŸG_iø½Ýn?«õÅQ÷`¾º¢]8àw`Ø^gVM¬‘k×„Ï9öŸ^‹‚-U–@<âÛD”©^¹ååÄ–jV«M»3ò>áë”½iîµÛùØî®þ#¿ùªŠiµUëºZºŠªNº¥-û—XVˆ‘­U‘ik%•RÅUhŽþÿö–Yk›õ[�Ö+ˆ�ë¦*©ë†Vª¡]¶EUówUŸ¦ÙŠr­*aóZ©«¬Ü¸»aËVØí²R¨j Z«[R*aZZ¯Ž¨ê 
¿æŠ‹Q«pÊ«£•mÔšMÆ5*¡ÒI¡–¡R’.`
¨úVv¿YŸWeâ¯žK'ú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´0úP>Èg>j¦B–-†Y`«¤rÐƒz¬XŒÁæ¢¦ªågkVbo;aeþXëYf…TI„š×jò,þšþªŒ6¨úøªŽßÑ\à…ITc…J7�±xµÓ	Fú*³üQr«ÖMê•+ŽbÂi¿&‡<D×°³Í�æ»E‡ ¡'·ÒÝMºp`Øt”E¦4Ž=—ØHeÞ0õéë‡\l|PN_:ª7]€Ø—³èl Á8XSÙõqÄÈwÜcâM`×\£5y¥àÅç§¹:ü5Ö–G��R�Þ¸ÎÃúðàà©£†VàOL€»0›hÓxÑ‚Sûòl’›�Ç KC^`aqY8FB>ÞSh%âÑõ*{fg©•zÚ©jUä!Fú¨e»aõ[ú\„ªÊ÷„ËGü‘TmPnº¾ª®3%¸ã£WUWß9ôÂ
Š�ÔN}{ª¼P—ƒ­4LÑŸVx¾¹"O$¤=÷­Eî$ß>v~Îã–ø§Ò8ôƒK"éð(Ôq’ŸPÍ0°8\ +#wOÓ L\~wÅáùÓ!6„TÏs¯Å	¼%0Ð,A7¯@sà›©’ø°*Ï~áèL±ªˆc²Ð Á>`UsÓ\Ãê§
ø>¨àú£·bº¾2›þâ_&Ÿ>¡!8gÎÏ4ñqñ3LKHLALLýg5|û¿ÌÊÚXÓƒqÐ«ñàTÀÒ5Íib“·¶�ßô:�êc¯ÉŠ"¢]jÝÐWNaösÔâR¥v§——ší©Z­¥V··\`g9uè…   =   F  í    §  Ù    E  ê    !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ü<?xml version="1.0"?><Features nextValidID="9"><Feature recentID="8" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4553-4569" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4529-4545" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4455-4476" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4491-4496" color="#ffffff" type="standard"/><Segment range="4497-4514" color="#ffffff" type="standard"/><Segment name="-10" range="4515-4521" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2443-2547" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3579-4167" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2616" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2548-2616" color="#ccffcc" type="standard" translated="1"/><Segment range="2617-3408" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="1" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#ffff99" type="standard"/></Feature><Feature recentID="0" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="72-749" color="#ff0000" type="standard" translated="1"/><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="1:3:46">2021.7.7</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  þ     å  «        «S£cãBÇ¹oðTÕ	Š±‹Šéïzë¤Aéàn9zô¯Q9Vž`ë®bšxZØFµJE�Ax¥�ØZÅhPEPQöaAÙgŠW¥JyPA÷¯k:šêïu¯Y�¹R¦)]½8f½eUêêýÕ€TJajÅJ9âžÔk®ëQ�Š¶¦T¥kh–¯Û†Ò˜ÕU^`:ç…G©½D`JéPE{eNé^•v›¢…­[š™ƒ•WÒµëÐfšb†9^†ië¶XQ¦y¢…ÖaQxPQÛn«ê_gf¥j´#…-J…gú)d[•Bhj•`Wk wV�g^eíÝbgmƒGWUµJ%*Waªyyyn•ªÑzÕi×hQ�L­y4}¦×Užõ Æâú§Ñ×Ú~/w[�êÅFýqTD}Ø/®„¨—N8�Ø6™Õ“k$Zõá3ÂÎ}§×¢à‹Ue�8¶Ñ%*W„®yyq%š•ªÓnÌü�¸zå/Z{­vþv;«¿ˆïßþj¢šmUzî–®¢ª“®©K~åÖ¢$kUdZZÉeT±UZ#¿¿ý¥–ZæýVçuŠâ'zéŠªzá•ª¨Wm‘U|ÝÕgé¶bœ«J˜|Öªjë7.îØrÕ¶;l…Tªš¨ªÖÔ…J˜V–«ãª:¨¯ù¢¢ÔjÄ2ªèå[u&†q�EFÁE
€¨C´�BE(e¨T�$‹˜ª>•‡E�¯ÖgÕÙx«ç’ÃÉÀþ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYóm>”²Ïš©�¥‹a–X*é´ Þ« V#0_ù¨©ª¹YÚÕ˜›ÎØGY†V:ÖY¡Ua&µÚ¼‹?¦¿ª£ª>¾*£·ôW8!RUáFÒ€�Ä€§l^ítÂQ¾„J¬ÿ\ªõ†z¥Jã˜ƒ0šoÉ¡ÏQ5ì,ógy®Ñaè(Iíô·ESnœ6%i�#�eöwŒ=zzá×—Îª�×`¶%ìú(ðNö}\q2÷ø“X5×(Í^ix1yéîN¿u¥‘à`CT£A÷®3°þ¼88*há•¸Â .Ì&Ú4Þ ô`”þü›$¦çqÀÐ×˜\VGFÎ��·†”Ú	x´}JžÙ™êF†¥^¶ªZ•A¹Q¾ªnØ}Vþ—!*²½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈM¡3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|LÓÒS?YÍ_>ïó2ƒÆ¶–4àÜt*üx04„ÍsZX„¤íí¤7ý§z˜ëÃ²bˆ�h„Á—Z·tÓ˜}†œõ8”©]†éååæ»jV«DéUƒ…mí×Î]za   =   F  >  S  ø  *  d  –  ;  m  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="10"><Feature recentID="8" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="153-830" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="2" name="COX8 presequence" directionality="1" translationMW="2703.40" type="CDS" allowSegmentOverlaps="0" cleavageArrows="146" consecutiveTranslationNumbering="1" maxRunOn="830" maxFusedRunOn="830" detectionMode="exactProteinMatch"><Segment range="72-146" color="#993366" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;mitochondrial presequence of human cytochrome &lt;i&gt;c&lt;/i&gt; oxidase subunit VIII (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/2543673&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/2543673&quot;&gt;Rizutto et al., 1989&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="9" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#ffff99" type="standard"/></Feature><Feature recentID="7" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2697" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2629-2697" color="#ccffcc" type="standard" translated="1"/><Segment range="2698-3489" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="6" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3660-4248" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2524-2628" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4572-4577" color="#ffffff" type="standard"/><Segment range="4578-4595" color="#ffffff" type="standard"/><Segment name="-10" range="4596-4602" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4536-4557" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4610-4626" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4634-4650" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="2:19:13">2021.6.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  X     ì  Æ        ÆS£cãBÇ¹oðTÕ	Š±‹Šéïzë¤Aéàn9zô¯Q9V¶» F÷ÒŽyƒ®¸UŠiákaÕ)â–ak¡AAGÙ…ež)^•)åAÞ½¬èk«½Ö½fåJ˜¥vôášôi•W««ôPkVQ)…«`A(çŠ{Q®»­F*Ú™R•­ JZ¿nJcUUy€`ëž¦õ�+¥Aí•;¥zT`AÚnŠµnjfU_J×¯AšiŠåz§®ÙaF™æŠY…EáAGmº¯©}�š•ªÐŽµ*!Ÿè¥‘lJU	¡ªTQ�]®�ÝZ�y—·u‰�¶]TXÕ(”©]†©ååå¸jV«EëU¤w]¡F2µäÑö›]V{Öƒ?‹êŸG_iø½Ýn?«õÅQ÷`¾º¢]8àw`Ø^gVM¬‘k×„Ï9öŸ^‹‚-U–@<âÛD”©^¹ååÄ–jV«M»3ò>áë”½iîµÛùØî®þ#¿ùªŠiµUëºZºŠªNº¥-û—XVˆ‘­U‘ik%•RÅUhŽþÿö–Yk›õ[�Ö+ˆ�ë¦*©ë†Vª¡]¶EUówUŸ¦ÙŠr­*aóZ©«¬Ü¸»aËVØí²R¨j Z«[R*aZZ¯Ž¨ê 
¿æŠ‹Q«pÊ«£•mÔšMÆ5*¡ÒI¡–¡R’.`
¨úVv¿YŸWeâ¯žK'ú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´0úP>Èg>j¦B–-†Y`«¤rÐƒz¬XŒÁæ¢¦ªågkVbo;aeþXëYf…TI„š×jò,þšþªŒ6¨úøªŽßÑ\à…ITc…J7�±xµÓ	Fú*³üQr«ÖMê•+ŽbÂi¿&‡<D×°³Í�æ»E‡ ¡'·ÒÝMºp`Øt”E¦4Ž=—ØHeÞ0õéë‡\l|PN_:ª7]€Ø—³èl Á8XSÙõqÄÈwÜcâM`×\£5y¥àÅç§¹:ü5Ö–G��R�Þ¸ÎÃúðàà©£†VàOL€»0›hÓxÑ‚Sûòl’›�Ç KC^`aqY8FB>ÞSh%âÑõ*{fg©•zÚ©jUä!Fú¨e»aõ[ú\„ªÊ÷„ËGü‘TmPnº¾ª®3%¸ã£WUWß9ôÂ
Š�ÔN}{ª¼P—ƒ­4LÑŸVx¾¹"O$¤=÷­Eî$ß>v~Îã–ø§Ò8ôƒK"éð(Ôq’ŸPÍ0°8\ +#wOÓ L\~wÅáùÓ!6„TÏs¯Å	¼%0Ð,A7¯@sà›©’ø°*Ï~áèL±ªˆc²Ð Á>`UsÓ\Ãê§
ø>¨àú£·bº¾2›þâ_&Ÿ>¡!8gÎÏ4ñqñ3LKHLALLýg5|û¿ÌÊÚXÓƒqÐ«ñàTÀÒ5Íib“·¶�ßô:�êc¯ÉŠ"¢]jÝÐWNaösÔâR¥v§——ší©Z­¥V··\`g9uè…   =   F  Y  n    E    ±  V  ˆ  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features nextValidID="10"><Feature recentID="8" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="180-857" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="2" name="COX8 presequence" directionality="1" translationMW="2703.40" type="CDS" allowSegmentOverlaps="0" cleavageArrows="146" consecutiveTranslationNumbering="1" maxRunOn="857" maxFusedRunOn="857" detectionMode="exactProteinMatch"><Segment range="72-146" color="#993366" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;mitochondrial presequence of human cytochrome &lt;i&gt;c&lt;/i&gt; oxidase subunit VIII (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/2543673&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/2543673&quot;&gt;Rizutto et al., 1989&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="EC_number"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="9" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#00ffff" type="standard"/></Feature><Feature recentID="7" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2724" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2656-2724" color="#ccffcc" type="standard" translated="1"/><Segment range="2725-3516" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="6" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3687-4275" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2551-2655" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4599-4604" color="#ffffff" type="standard"/><Segment range="4605-4622" color="#ffffff" type="standard"/><Segment name="-10" range="4623-4629" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4563-4584" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4637-4653" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4661-4677" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  “<Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pPD95_67</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="2:15:45">2021.6.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  å      Ï  ´      
  ´S£cãBÇ¹oðTÕ	Š±až]—d]ªÐAþ�|NÑUaã½QE2PŸ	VTEê·�(¿Zè¡i!ŠXÕªâÒ@…c]œz¥jj7ž^~+Ø	J•Ù™ž^_á¦¥j´õÞ‹yêâ˜"µŽ»ŸÑ¶a\6ªÔHö?)‰ÐT^fªÕp�GrR¥t¬'——ÙÙ©Z­áKR¡BþŠYÄ¥Pš¥EÚèÕ Y×™{wX™Û`ÑÕÕE�mR‰J•Øjž^^[†¥j´^µZGuÚ`S+^MiµÕg½h1ƒø¾©ôuöŸ‹ÝÖãú±Q¿\Uvë¡*%ÓŽ§v�…æudÚÉ½xLð³Ÿiõè¸"ÕYdÎ-´IJ•á+ž^\If¥j´Û³?#î¹KÖžë]¿�Žêïâ;÷ÿš¨¦›U^»¥«¨ª¤ëªRß¹u…h‰ÕY–²YU,UVˆïïÿie–¹¿U¹Ýb¸‰Þºbªž¸ejªÛdU_7uYúm˜§*Ò¦5ªšºÍË€û¶µmŽÛ!U*�&ªªµµ!R¦¥ªøêŽª «þh¨µ±ªº9VÝI¡„ÜcQQ°QB *í P„‘Jj I"æ ª�¥aÑgkõ™õv^*ùä°òp?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC¥ì†sæªd)bØe–
ºG-7ªÀˆÌþj*j®Vvµf&ó¶Ö_á•Žµ–hUAD˜I­v¯"Ïé¯ê¨Ãj�¯Š¨íýÎT•F8Q´ #q )Û�»]0”o¡«?Å*½a„Þ©R¸æ Ì&›òhsÀÔM{<ÙÞk´Xz
{}-ÑTÛ§‡IDZcHãÙ}„†]ã^ž¸uÆÁÅåóª£uØ m‰{>†Ê|……=ŸWL‡}Æ>$ÖuÊ3Wš^^z{“¯Ã]idxÁ•(Ð}ëŒì?¯
š8enð„È³	¶�7€=%?¿&É)¹Üp´5æ‘Ñ³„d#íá¥6‚^-R§¶fz‘¡©W­ª–¥PnBoª†[¶U¿¥ÈJ¬¯xL´ÉFÕë¡êªã2[Ž:5uU}óŸL ¨¨ðmDç×º«Å	x:ÓDÍõg‹ë’$òJCßzÔ^âMóçgìî9oŠ} ã�H1”².Ÿ�íG)ðeÓ…À²7tý:ÅÇç|^Ÿ�2hEL÷:üPPÁÐ›ÂSÁt3q:ô W>	º™/‹¬÷î„Ë¨†;- æW=5Ì>ªp¯ƒêŽª;v+«ã)¿á® eòióê†|ìóO4Ä´„ÄÁDÏÖsWÏ»üÌ ñ­¥�87
¿L!3\Ö–!);{iÿC©Þ¦:ðì˜¢ Z!0eÖ­Ýtæa§=N%*Waºyyy®Ú•ªÑ:U`á[{uÆs—^�XV   =   f  ]  �  ¦  ¦  ¹  ¹  ¼  ¼  Ó  Ó  *  \    3  m  Ÿ  D  v  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ®<?xml version="1.0"?><Features nextValidID="10"><Feature recentID="9" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#00ffff" type="standard"/></Feature><Feature recentID="8" name="GFP" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="167-580" color="#00ff00" type="standard"/></Feature><Feature recentID="7" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2450" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2382-2450" color="#ccffcc" type="standard" translated="1"/><Segment range="2451-3242" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="6" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3413-4001" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="5" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2277-2381" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4325-4330" color="#ffffff" type="standard"/><Segment range="4331-4348" color="#ffffff" type="standard"/><Segment name="-10" range="4349-4355" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4289-4310" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="583" maxFusedRunOn="583" detectionMode="exactProteinMatch"><Segment range="146-166" color="#993366" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4363-4379" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4387-4403" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  “<Notes>
<UUID>3b688286-664b-466e-b6bd-1c0080e65fdb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pPD95_67</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="2:14:55">2021.6.22</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  
(ý7zXZ  æÖ´F !   t/å£àtÿ	æ] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷Ànï¯ô™{ªcV 4ŽéŽ�ƒkôuH2h„Çµ›ùÀïmvüNÔ)»)|´VÝUcª˜!mWÖÅ`¸k¤ÒÃD¸øZ{Z;Fà€=0éI†.[L¤œ’9›dÙ wÆG,ÛÙÐQ|‰¯+ñ—f¼×É� µÏ±H½1@¨AlÒzBmNL¢ä.ø¥¦ŸH²aÌhš¾„¼äÂS’ùeF}v!°†Ö&Éf�Âúê��®Áâ¢@_G<Æå-:û““•ƒ{"’ç9=Ê„ÉjÊøã¾¬˜X/FÀã4âB£CB<pºí6SØá]¥¬õi¸:›‡¸ZñxŸaÜÕ�.è¢ß„!¤ŽåS™ÊLr×@˜Z(lï{4©ÏÁ€´¡Ì:JŠG%D¥ë�9°ùÛ½~eæKØ£/sâá5h©9­—Ðë×ìoÔ¶Š5’.ì&-Š�~Œ¯Š×Ô‚Oµ'ŒJ=·²³[	›f„OVÉ!ò!<Äw”Åb_1ã„Ã¢Åà;»>±0yxDªµ²è79¯³bí[½ç]ç‹5J�¯t- ÂA�È¿·’AìÍ\¼ì\Ç…ÎÞ“Â*F§KÛÂg]þÕ´^º¹©:ˆÙtq¦÷Tšôæ?�çžíaM…ÅòO’=_ÛT`Öxßçrç‚ƒ¥ +~Ï¹pQúq5—Ý†Jš›®0b?dÀá8Â‚M>¼X"—|ªW:Q•yWý¨á·DdÐÃc 2§�A)×ÜdäEh2œ-yÍ¨Dj©Ü…Þèõß“àT�€­¡“‚?²ØL’ìã™‘ºÒãÄÍÓªÙO[±!Oš¿”§›mTóˆÐO…¦ñê®'	¯+¬€
2þ†HïöÈ@ôË‹Hƒ„‹FE¾¹35èÏÈ£ç»Ãb»ìæ¹`ŽÈ¯ol%!^[ÿDí>N'Dð?©oãÐmËh®Y|”¼÷6ÞúHÁ–bð�Wfhâñ½ÍÈN8yF~çùÙLô¿ö×¥s`YU’ìH ‹«(ê7Õlá�°êAtËalnÅ#	‡,ÞŒ;ª§þÞUÝõ¯Œ¦QÃc¶‚c{†m£LÊ¡
ý¥“ ÙþPï†˜ûn,o$ÇÊ¿”o°�+ÿ¨ÅÏ…zSE2¢‰/{=Òí¼„fÐï‘ÃÌ™?æõ¥˜…¾ÊõéÍÇÂ%†õHåã¼ªšXâÍ^:_OZ„¯kW£™9.CïÏXq
áöòCÚ+Íc´ÞÕ¦ù¶™8�Èë‰èÿ´þiÙUž‹¢ŽÄsKæ®ƒ9h>IhÓ|p4[©ô†ô³ËwiäÙaòÕãå,0òwê¸«Üºx¡>ð  Â•Ã¤_I‹�«³ÝÑ3=cºÛ}:Ôk±˜"<
ÐúÛwŽÖ/Þ2Ê{o¶ÁÓt…¦�ÿ©kùR}©CØ÷ù€,Í ‘X¬L†ç5�Ã^-è�ÍÈfäKSû0ûqU0Í6n¤':ûPVžÚþœ�ÅÂ}O²Mz�Â“ÚàÃÙ3½xé…ÔrQDõ½…å(Ìq*¹BÖç=u/ZA3t‚Ú»™ÌòºïÄ@�ó(ðøªå�]»S-w½\’.ýz{ÐÊ=7e\Ì°³sË	'§°Æx1A¤ÕžòíÜ§K!¹ìs�‰uóm¿>egx\ï�.ý p8©�vÿº¹w°ø‘ÅCÿxe8<M…�Yyâ<9’9Eõ¬{�Åùõ„ìXë¨Û=HGR—ôŒr7ªx¼$‡·i0©³·JÐ¬{d<Ö�~œa ÂA$+šT\v$à¶Ë"Ús5¸ÊK¤ç+}¬ÚêÝ�•Š±ºªåZc¾I õI%Z™ßšŽúÎetRnpÃ$ÈµîLëí§,Ú»ÿ²¼m_ÜfŠÞšjRø’ÊÇÃ³s¡Ì· Å‰	_]¡j|à×²Û‡	xH›! âóª7fVW+~nZGá1¾?:]ˆœijðÑôÏpj¤øQ¸˜S­ýÒñ�ÊDqlêÇÒû©‰~ýCKÛ˜^®¨s:y²ÄÚ´ˆìQµî,>°´Ê‘)î¡¾´¬üÄµUwwe§‡2ÝÍÓ—Ëf€@’ëá³¥}ÿ_%æ]®†DœþÐº/Æm�+©#©þI!µ¯Ðw±@ñ»t¥²›eq0  ªUÒ»âê�Ûùz¶’?�é¤WèÍE�o"”-x¨wú‹k±¿é‰¢ê�‡xO>ž¼Ó…*Ã7Ý¡ÑÞÏÀW¡Îø‡¹nø•órAòi0JÆ­‘¦ÜÌB Ó%C/´È5d?°Ô:@u•(_râiŠpvâÓÆb7ÐòŒTb¨XDQ6e¾¼èFbÎKT¿rö¯½³›»!Ürú“^ªãŠfEîèœØ2tœk¦ääÊíþð]á)œ%·k5ìô‹ÍeÖ9µtÊÂåx¿ô"˜0Ö6èý±r‚	ÊŒD6—!«àÚ—”áJj¸ÊïòÕbÎ©ò`
±5·È~�éH�EY*Á£¯"ö¶ÍÿÛØÇs¬êÒEÑc£‹Ó…FÿÚc>¦Â»›ülHwÐ¶ˆþkÇd°ª#Ž*ïP¶Þé+pÚ�]Fˆ;50±‰Ñl¼êY@ê‹|?(³ËEv!m@ª“ »ç)W¬¦ª1Z9	ˆ\²Ý&©—Ø~ËÉ}+–¢â‹Ý'ÅCOœU †�)ÐC’Ô›ø;dœ\šŽ·€õ·¿ÀŽ§ü*©ü¶[­TlKÅÎÔ_ ™Cv¯„!Óà@‹M¨$^	¦€Ot™DóÊÖ�™8ÿÆß�m¸ò¡¯×½î6{œƒá±Ü/ÕŒ>œ»”wÅLI3§�T‡ÙÚ	%­CÔ‰‚B‹
8ªgwÓæAŒi©*ï ’¿¬_Aö½½C¡™J×O‚‡ó³-vb4Àw2æ7ŸûÑ(”U„)}àC˜°Ë§ˆîMÄ€x�þ	™ó¯Æk§¿2(<[§V:9Þ”ÅH<Sâ˜4[úÌYð¡tc›="EË4ª´˜B{¯VŠõñT"å�u³ÃK]ÉIô¼™ŸÐƒHÖF5¹Øán­(þò“íNÁ¹”ô5iÂrhß]úe ˆüÊbà'œOBxÉmvùA­ƒ^XajŽä&æçÍ´š»é³ˆÛµóíRVÇ`3W¾µÍÐGpI«‡; Wýþî|y¢!ã“üzwh6C0­ J|ùúlêÃ¿c5ùÈ9‹dp‰Ä{Ñ¯œ–´ol�ˆ{ZQ†kGji!lyŠÌÈú¸1;     ÌŸ*0�ó— ‚€ê @‚zU±Ägû    YZ  ˜      �®ZTR

BASE      yµ  xÁA�AÄÀ£fåÃL 5�%PüuàÊ‘[m²¢´m*¥ lüÝ»ßÝ}¿÷î÷î}÷Þ÷î½ïÝû½÷½»»ïýDÙVŠ›¸† �,×‚3ÐØ4€Ä EV5–bÙ6¨•%’&Y�:T-¦ˆš IFLVl+ ¢r,–,¶¬�ôwïýîî½÷½{÷îÝûî½ïÞû¾ï~ïîÝÝ{ïîî{¿ÆÊÆbÕúiÖ W_û!±iDû9’U5s#·	Zd„ET5@’©°ÈØïÞûÝÝ{ï{¿»ï÷»÷Ý{ß½÷}ïÞ÷îÝÝ{ïîî{?s	6°4‰meAM, �’*@�µRÆ€RˆÁ"Xc2b4Ò! ¤Ð ëwïýîî½÷½û½»»÷Ý{ß½÷Ý{÷ÝïÝÝ{ïîî{?X �1%H
Î,²Q4@¬J'é¶l«bCÅ–mŒAËmÕ¤m0Ddc¤mµ+ƒár©c¤#%aÂQ3„Ú`‰sÓæb£Ø`eK³„êæ²Ñ�ß½÷»»÷Þw¿÷»ûî}÷Þwï}¿÷»÷îÝÝ{ïîî{¿Ñšs›¹µdµÀ6(Öj0Ú#×ªµ-smcÛUY VkÕ*«
W«[	”R „‚šA Ø Ê\ÛÚ¶�‚ ¨EÛ ZŒAÖ2c¬VdU±ZPU	ŒF ›c ¶¢YÌjX‘lª¢ZÍ1[êÖÉl@#×h& V)FU
U˜€	Tm¹*W•jµmQV6�j¢LgU+@c`”$ŽI¤)Z©•è¦ ‰!XT¦f‹T«r+ BŒÚ0‚eµÅÂ¦›1u[5[sÎjš$ÓØZ2F×6E¦�áÊ–�SrSqÈÀm6Ô9NÍÒ©ÙT—®`‘ÓÑ‡”±DÌ±9ÍbsÉ(Äæhèt+P·fs‹ª-ÈFiµBfCÓ±ª©™s
Û•U- FˆŒ6×HdlKr5¢@AŒÄ¨Á¨6³¹­¨mUåtT¹Õ–U¹Æ6æÒ@r	Ò°ÔS‹Ñ„¥´Ãi m%bÕÜ6A˜U$‰cU€µ\d:§Q´Í(™›:kÚÜ1µ†�¬´ÄXcÃÆÀÑŠ)éH†�Es¹l$&ÁXN7X±Z2˜4EÙÅ›«*Ç`¤*�ÖÜJš¥Â¦¸„7b&g26&¹e8HƒYÎ‹‚¥+ÖÂÕ6
B–’¢S,‡²±ZÎ5ÝV›.]ZQ.	h)nš8S[s�r8–ê†¤�ÛÚf4Ã¢Å˜L:X¤$L dHs‰„æÖXRà(–ÙÀŠ5"bRR¬FUP(-4AÚª’ 5’ m3±jÖÆgC¶Í@ ´Z‰´UUË9ƒ–Ë• ll.6œ¦••›Ò@\l°VÕ&h°t5âË¶Z˜áfXèÆÆj ¬e86·±5×rA[¦Ëå†é$°™­ØÔRÖ@&a±)�Îá´©K˜ªÖÌ1†Ûp¥8a²ÅØ„%[gâ(pnÌÕ6AE@§�6œµ)Eœc¢âjCU`ni´Š°-›ZÍ�­%+q6©Ê$×l¨ê·H˜æt«ŠiméVåÒ­Ê5FÖª-gÑ¶%µL	6£ØÜ*1qIl®¹9Ü„É&ÎáÄ†‰§ ÎmsÀæÖÚ6ç,Ý¤FA—ŽÉÐj›,œ:Lœƒ9(ÈÄÂ5Ö(tlºŠ±Š\mºfd™)”‰S‚A5ÆP`¸H6’bnàúÝ{¿»{ï}ï~ï¾»÷Ý{ß½÷Ý»ûî{w÷Þ»»ûÞW ¤K ±Æ`’sÁ`¥@ýp �  i     T®ZTR

BASE      >&  xÁA  ƒ°YãúÀ þµ,9·j#RZ`E0ÚpIÔ†ÀªUÛ”�
ˆEB5ARËÅ²X©ÕZ$%«Q`5J± ÚFKR6,r  ,RIW‹% «h‘k(k¸VÀ
�e­,¡´¨ˆtÀ†5Xm(QY’XI«5‚)bQ–0ˆ„%(Èh´ª­§›1¢ª†æl`%hÛÊ‚šX %U€ )0j¥Œ¥ƒE°ÆdÄh¤C@H¡–�0’*,XÐ’
¨Âj …ŒÁ(ARpÖ`á��¢Á bmP:I·e[2Ø(¶lcZn«& mƒ	 "#m«•X—K¥ØF:R1 5C¨Áç¦Íb¬l©: ‚P�+G,`©µ=A‰*Â  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  w     b®ZTR

BASE      LX  xÁA  ƒ°YãxÔ þµ,¹mdƒ
¢0W¬XLVf£!sS�¢ª!ÊV[ÐsèæLV”á Õ"V’Ò”Ö‚T&³&6”Ö–™U®¶‘•¶É¨µ6dÚjÙÀ†lSr
µ±¨Z� -›±8KÉZ­eP5XÙ * ÅŠ i`!X�RÊªUË¦4Z„ÔZcE¬¥P­¥0h•’e�Zæ(£@Ø‰–€5,™h¨€hÑæ¦³€`4Z––¬¬$j%±²¤hDÂ*&	‘¶Áj`[U1%bTƒ„´4%+XcV4V™V00%³6–•,³TR‰UU5	lKIFÛ€ShP��”¬Á  k,d¡˜&Y$aVj5Òr ¬*@7 µ�­ÀTjƒÚ ¤â€¶©V³°<�  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  F     1®ZTR

BASE      �  xÁA  ƒ°YãxÔ þµ,¹Ü0¬HJÖ`Yc�,&˜¦d9 $,+µj�–Û€¬* l ±¶-°
H‹6 m  Ra6`ÛTµ °
V MM‹mZZª¥ZR)P¶©º•–V‚U€j¥Z¥ €Z*l€ZÛ¦Õ6¥tÛ@U€)è&mÂ
*«Ö¸AZ®m°�R¦U+7€
Ú `Á‚�mXàV›”mÓÀ¶JÛ¶mAºR¡T-„é )Ø6€iÛ¶)´Ñ†…%ÔæÚ¶Ò6uU²rÐM·é¬AÐ:uºmæ¶jsPÛ¦–¥›i:5Å†él›³\º•n³rnÎ�9¤03Q36�ÛH|ÿ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  f     Q®ZTR

BASE      ;  xÁA  ƒ°YãxÔ þµ,¹ÍMgÁ£Ñ²´de%Q+AˆE�%Ec° V1I� ˆ´VÛªŠ)£” Œ ¥)YÁ*³¢±Ê´‚�)™µ°¬d1˜¥’J¬ªªI`[J2Ú˜Bƒ
¬h€¤dÆ`�5Èb‚iJ–J³R©iÙ6`ÀªŠ Û ’ÙF«@¬)QÔÚ0ˆT˜ƒ6X[šV,°‚U ‹¢¥%Ñ–¥eZ¦%TJZJ�¬´”2°dÒ dA U2LÉs€„VÛÒjSHÝ6ÒŒ±Úd“&Ì¢’Jaµb.RrµÆ•L©
f6€
hbÅŠ#i`!³6$mIÌVik¨éL„RD�pL7˜¬Ó¶­4Ö00¡ æjN±©«d¹°Ím2{E*J  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  2     ®ZTR

BASE      X  xÁA  ƒ°YãúÀ þµ,9ÙH )æ†ËÀ
I+,XÔP5Ä éh¬1˜¤Ä\0X)�@àÊ‘[m²¢´m*¥ l4²šk"éjµÈ¢XB�Dj€…�‚Â² e$ÔJPEP��HPFËV€ÅecµQs¥µjmjƒHiVd£—DmH ¬ZµA©©€U@A0]Lckmm[Š‚ÖFA ´•‚Õ¶¶$aÃ  À"U\m±em’`[€ lÀÕ
X’¢Œh™´A-
"À°±†TD&¹XB¬mAB12”È‘5VœÌ±~/ïY  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  F     1®ZTR

BASE      ™  xÁA  ƒ°YãxÔ þµ,9æˆRF XY©6J mÀXT
Àƒµ™n¡Ê -µ`°ÁVZE°TÖ+*ÕrceÁ& €Â6ØÌÜ``�Ê 6X°@µ`K´ Ø`Ã‚lkƒP(¨m€º¥hê[[�¶A¡¥l A
mm(TÀ6Ø ,Ë*­Àm:--*¨Êm[¦lµÁ¶‘j[ 
+€�Ú¨ Ø -mCjB”ÂR•6JË¶1°
[°
´�
�t£ª`
RØ€m	ÖÆ†R$ ¦Ð6…mê–V…¥ÀÚR¡lZå€A*:`ÆP�ÚJ+³Ú`µ*SkÚÚ¶ú ƒ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  =     (®ZTR

BASE      „  xÁA  ƒ°YãúÀ þµ,9µ%TÅš……!¬a¬XK’átÛ¢¨JÆ†,Òp²é\ÃR¨Å„\TFX£�ÜÈÚ†Ãe1`e#ÓÖZÕ,•VM@RfÊÐ -[€2Ô�æ¥U–iË…%ÌÕF«A–Ù‚*ÁZT@C
hd¬¬’Ú¨UYÙr#ÉˆQfb–QTfYm´ZÐ ¶*X“ZÔhl5`%«áØ "#�n® �$[m5¬U#ÊÂZ�"¢�Ž#¢-KXZU¸!•Pƒ�ÙÖF«À
ÄU$Vk«@X­•`«†!¸ÚFÛ«ªrKÛhH>ü¨^  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  o      Z®ZTR

BASE       D‘   xÁA 0¡ZÛÉãà_KáÉECª\µeË¸êºº2®Sët«Ùl»Š¥ÛàbÃÝUUw@²ÝÙ�£)  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  =   	  (®ZTR

BASE      „  xÁA  ƒ°YãxÔ þµ,96ŒÑhYZ²²’¨• Ä"È’¢1X	«˜$HDÚ«�mUÅ”ˆQJFÐÒ”¬`ŒYÑXeZÁÀ”ÌÚXV²ÌRI%VUÕ$°-%m
L¡AV4@R²c0Èd1Á4%Ë%aY©U£4ÝØª‚H7(r«ÁV V iÑ´m €T¶°-5-XÅV ›šÛ´4MÓ4¥R mS	tK-%­ Õ¥J¥€iª°Zhm›Z›J©Û K€)èæ6iÂJ*eµBJ®m,(�Ò*˜Ù 
h ­X2H«ÀBV›´-	l•mm@Û¡2þ
  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  1   
  ®ZTR

BASE      V  xÁA  ƒ°YãúÀ þµ,9%[RÌ\VÀHZ±`Á¢Ö¨€ª!® H—@c�Á$%æ‚ÁJ�WŽÜrh“µ¥mS)Ý e ‘Õ\IW«%@Åj$R,„–)#¡&P‚"(‚‚lD‚2‚X°, («�š+•¨UkcPDJ°"m¸$jCŠ `ÕªmJHÄ(¨ 
‚¹b[Chkkm	ZEÔF
TÛhIÂ†A € Upm±am�b[€ l� W+`��(#ÚÒ’Ú ‘`ØXC*ŠLr±%k‹DŠE&£D–ˆ¬ÑªYòï‡  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  Á<AlignableSequences trimStringency="Medium"><Sequence name="pPD95_67" ID="0" use="0" sortOrder="0" trimmedRange="0..4531"/><Sequence name="23_G5662-F1_TSS20210719-027-07229-09_E12" ID="1" sortOrder="1" trimmedRange="4..1059"/><Sequence name="23_G5662-R1_TSS20210719-027-07229_B09" ID="2" sortOrder="2" trimmedRange="90..1102"/><Sequence name="23_G5662-R2_TSS20210719-027-07229-02_H12" ID="3" use="0" sortOrder="3" trimmedRange="554..903"/><Sequence name="23_G5662-R3_TSS20210719-027-07229-06_G04" ID="4" sortOrder="4" trimmedRange="12..1048"/><Sequence name="23_pQE30-F_TSS20210719-027-07229_E02" ID="5" use="0" sortOrder="5" trimmedRange="9..759"/><Sequence name="24_G5662-F1_TSS20210719-027-07229-09_B03" ID="6" use="0" sortOrder="6" trimmedRange="7..83"/><Sequence name="24_G5662-R1_TSS20210719-027-07229-02_A02" ID="7" use="0" sortOrder="7" trimmedRange="0..891"/><Sequence name="24_G5662-R2_TSS20210719-027-07229-05_G06" ID="8" use="0" sortOrder="8" trimmedRange="4..136"/><Sequence name="24_G5662-R3_TSS20210719-027-07229-06_B10" ID="9" use="0" sortOrder="9" trimmedRange="2..895"/><Sequence name="24_pQE30-F_TSS20210719-027-07229_F02" ID="10" use="0" sortOrder="10" trimmedRange="5..763"/></AlignableSequences>  ñ‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*Cº Sá}6   ‹     ÿ BC …íœÍ®m¹QÇ÷é2BtY–p�@mËH–˜t‡&	dÒ¶JÂHHô 1ãz€Ä´m<°Ä€"µ¢<@#ñ =`ŠÔ¼A‹	#¤ ¦áWkï}Ï97­$ƒˆÛ$«îÞw�õa/»\õÿ¯ryíOëòB^ûñŸ¸7Øþ‹\žÉ;—9üðöåò�ß»\>ûŸËEÚn¡•æ{vsT)iÝšÄ×EÇÚ³†:ŠÄá‚—¸wTN•Uµ»ìK¬"¡–6£T/­S$é8vêàXÙÓ­Ú×L²ËÚ5Œºz][–Æ({—»z¯Kt…Æ}r·]ÚvØÍ�¢"Å•>ãÒá÷à¤H‘T*—pÝôIbY“‹©o¬Þ§¬2g­#Å:C¨’Í¤õÞ¯ZªžËFT¡�!p\êrZÝˆÞ¹.}‹ó;w7øGÜÖº¾Jõ“³§jº#£†ì·Ðï]÷¦ºº*jBAÖ;•Ýn:'kŒ8ƒÆ%rÝª!J_×­°�™ëÖ#)SdÓj«>(Ê�R|¬)ŒIÁÍV««¥5ËÉ;á;1ÆPZbä¤¢õ,RkM.è,s×¾»Ä¶
Ãì8W]¨ÀIðqgz3£[>'�mXu‚ZÑgÁkË×ôþhu©}­Î~„[«ãœ­¥ÞJ©eOG¡#q¦WatRém&—ÒØ{më
£;ç–=ÙßÛÓÆ-=¦9P™„µFÝvw'Ì.C¤Ó#;A])ÑÆ@Óæ §2]ï“2‘jBßh…Ò²½•‰‹¤†Ne¤"æíúŽ}‡š<hDŽy.Ms†š§ZgÇ ûÆŠ©H¹n
FPÅÊ	-ßi•Íg«î™JX{M©è_�f®ÞmPQô˜Èò1cå62ŠÇô­“\ ó÷£ú]G ­¸Äè½jÜË|¡Æ\ “ƒ1qAJßi?5u§6Ø½äœ÷Ä‰j¦mŽˆqE”­ÞétÞrø\Þ0†)jk=6í}ÙYÛjkhjƒëîØ‚_1-FÃåëÊÏ>v¦oJë´•¼‚ký<+t,šQAX0·YÍí�µÊZ9W‡Ž6ÊÃùÅ:%!ô�¯1˜Wó^Ê‡%€æ†jvta'™ÊØ	e/\Út“0	G—\€?Ä‡¶Ð°G»ÍÕ®Ï« ÐÄ Ò®8Âl)KÅ0S¼H°žºæÜ±ÍÔÃr-+¨ÝÄ%2XPÂÄ;—ÛŠ3áÙ±£Áò·Só'‡wxÙ¡ùU°—G± ))f�NrÈØFõ€XÃ8^¾T±6°¢•òŒr¥K¨„!¯Ùçåœ™Oé>r'êÙ­‰™f0rám§ŠâžÓmöÕá+—Œ­$-üÃÚ›ùFQŸ°½¼ßÕ1Fã–6ºc$¦„<úÀ·²Sõ9¢¡ºŠS‚®myÆ¼•K#jÂ;ÈÜÆ�+šuöÀ¸ÁÊPÀO…MÌÓÌw±£¼<f²“!Ðô.�GŒe´ Wæ0L”,—àÇâb©|î
~`Û�Á*ŽáÂñÐðp˜tlÞçbcn€åÄµ|ê~ûÍkM¥©\É¥´°*FVK[Éƒ²@î·õUQÑ÷ÍÔÄo$«ö‰¹9ŸbÛê³dWƒ\Œ…Fl½¢/`«³AÅ‡�ˆÊ3ŠÖ¨×À³6‹‹îäU§â‚=FÙJ¶š‚à›eNüK©ïƒ)]‹Mrn¨Ê)¾Ñ™ðÑÝ¦÷,�±4æ,�ö3¸ƒ~cÉØ]rj>1¶‰føÌhs'\0ã…9E|\\“��& "‡Nhr4ð«°µÇa¨Žf˜öÚ÷žahLÉ·�áf„üí ßæjÚÃ†ºè²/XD€ŸZôåJÆ¡â^FÆc—x%c4h©BíæSJë ¨×ˆãÇ§œrÊ)§œrÊ)§œrÊ)§œrÊ)§|åä~íš§úõ‡kë7øûwßxžÃz÷¢üÿ_Ç÷“Ûöãï\·ï?Ü¶¯]·ï<<^çù¶²SŠMÞ÷!qÆ¶B˜±î`™ˆÍùX½¥–Š÷;Ô°³%uÔï6J%ú0·%58¸öô[Â«ö(>WPûXQ¬Ê •ªÚ.n‰w{Ìè} ¶2D½¸IñÂß|ì..Œ¹û0Çcµasœ–û™QC4{š=Ê¤øï†•Š–êªÜH¥ÆÊžeKÓÔ~ysXéËrXRjk¹çíî),Õ{
Ë2ž´Zý¢}¾ýª�þ”SNùŠËÃ×®ìóg7fúÍË[—ï¾ÄLß¸üèÍGfúð¶}ÿÎP/íß™ë¯nÛ�^ºî‹?ºn­¾ÅW¼¥y-ÑêímË)µ_Ð0AuÏÜ�qÇiË/Yâøì�ëA_lu·³¤4}GHÆ°�? %¡âPÀÿõ5ã/7–Ba¾ÌQ¨­ì�Àb¸nn[à!%iüíØ…ÖjÜáXæ1%¸1h±œ»ßÑíä+ô58»
×³ã6Å�ÃÒæÕÉX¶$ö.ÄIGè`n9w_bÐÛ’ý>Œ¸´!]/îßƒ‘�Tã`i…y e˜¡j‹¨'.K;(…Ë&ä}O1í[Š	ÜRLta+úL?Åée´U…aÐ4•ž(1rÊ±Ã�çJ…gRt•g	JÅÅeeÑøá|ihvp¬éT¨UF³{Ù�«Õõ¢.26_3Äzm5u•£Õì{áv'¥�rÊ)¿hù¯7¯D÷—·%†¿	þýëÏIð÷/?J�á×gF\|?½‘ÚÛo\÷?¹…eo=Üöoç?½]Û>¼í|ÛÿèÍç$jçÿšo:V<,[Fè=qËv­ÍœS«Ò’JRWmùB³å+YlkËÕ”ÃlQR&ðK¹iç$!â€3E“BAPIVèË¥˜AüÐ«·ÅmÎLÇ¢
o!ÔB4ÔUUlðžˆ“-j  TBË0© u™`ãa·ÂÆ8Ü
-jëa¸,>‰b¢-jðP‘Û-Î3¬fËÍúL³¥š)¿ùaBÖ´z[‰>6ÝçÙ€çˆ®š6lÅM!´ƒ{õøTßÒð¨&X‘má(O Ã+**öØQ «m’¬K�†ÑRúÑ‡#2íÖ•Ø÷õñ£\Ÿ? ,{ ñp:�ÜñtÐaðv¶<ÎVý]ŸAf°G?ó[¯ÚÂO9å”òƒÛ|ÜŸÊð=€ÿõ—¢ž÷.ÿúàß¹m¿wÛ^žG7w ÿìý|ð~)*âÁ85°$ep×ióë¾–Œ‡],%k ±–ý³’ìçX#ß&!QÒ 
[Õ\ÀùPm±‹2T
aŠró0«�Õë‡� pä¸ØÔ¢�n…z�Õšqg]â˜9	]f¼N\ÂËú‘|!‚J;èrUòè†#êûY ûüÒuÞòeN9å”Ÿ”¼#ÿ)÷`ärùîKÁÈ\¾ÿ„›>N·™µ[PqyýqÆÍö?”ÜgæìøGÏƒŽ·_Þ>¹þ¿i•1Ž¬0rúUãaÏã•éZœŽ4½Ì’lv’ƒ�ê…ˆA8¶ê•s&œKŒGÎñÇÚ÷aT`œcÙ(éÉfõ$QyÛO“e¡ôJ#ç b¸Eb�…°j[o*q3Á3aÄµJ¨¥ò�önRvÍ}ôª­ø”S~	åŸnàüÞ-]b»?x	œ¿yÌÜ|òú#ˆê{—K©%ÿ´|¼�FËoÌÜ�Í©¤�Êð6¹Ás#õx�P6{o‚=.v±°¸èÕf%ÚŒŽJxxµÇ §	Ê)¬ö:Û,Ã1V!ÌÕmE’½ë§@¦¤Ü“+)W›�÷]�I¢Wì-&µDsJ¹hïòI10–2÷5Ÿy®-ÜÂ^†ÚYhN¾/›†¡µj§•Ç{RËòñ6!$T]ÔQ!ü0b²ÔJ`óÿÕKtQlv‡‚4Ö&—ŠMÐØ;a%$½¦NxfO´M�X:ƒ«½N#=ÒÐ‘¥3$£-©½låŽŠ©fõdÙ“¹Poæ9}&Çh®Il~hnƒôÎ€øTVZKû«¶ÂSN9å'åonèüï÷Ÿ
xëò·/¡ó·.~ë1mH}®kúûn¾MòÔ3-|Ê)¯X¾ùpƒ×+\ß:æÊŸÊ·�®÷ôï]ž§H?~ãq_n3ë¶½§Bë3×#>·×åm¶@®‰8ù)‰¸ëjV›¶å¬#Äñª5õ²üñ-ño·ùžo	iýá%_W`}ðð<çp×èM^“ÎÇñ'Iç/ËYÜ¯ûœ»¾Ë7½þ8'ô"‘}Ÿ+ºíðÚó9¦ÏžÔ)—Ç¹¦û(~yž8ÿâž?ùºeZ¸gØÉ°»¨–ØpÆSb/÷Ã€åø‰‹,`‚bìÕ,.áy�Ñ�jL–ôã˜_J·D2&1“Ö �èèI"Y-³½	sV—#‘,ª�‰nµù¥šˆU(¢G"›º~<ôf‰ärM$'K$K-×k"9‰äò4‘<^$’%Ýìwök‰äz·ßŸ�Hþjç4F'8|ÿUûÑ)§üŠËßÝâŸÿ a_‡Jì—Óþâ%*y÷�ËŸ?á’O~ç‘þLþ!ßO^{ž'øâ¶8é£‡GfNO0ý�ËóÅLVîû–/ ˆHG¾@Ú‹˜£\cŽ@ t�9Íeµ%!–�ó:2hïŽE<2|Yq¥uÖR¼'¸ÈJû»dcûÎ%ƒi6U%tàÊ‚±òƒÏòxâ«Í6r<KXÅÙGˆj@µ
¶Ù�ÛYŒGÜ~Ï¶ð³Ÿör¶pu¬:ÇÏùvÍ°ÏºÏæ•‘»+6›7KI´H®±ì�øÃfóno×³y×(tM‹Bm6�{Ùlûž	©áÈ¤E˜yÍŒg[Ô§”j³`½ âÝ†æ–2à©Ÿé‚SNùEËÿ.½Ò™ºR  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  J<?xml version="1.0"?><Features nextValidID="9"><Feature recentID="0" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="4566-4582" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4542-4558" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4468-4489" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="4504-4509" color="#ffffff" type="standard"/><Segment range="4510-4527" color="#ffffff" type="standard"/><Segment name="-10" range="4528-4534" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2456-2560" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="pUC ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3592-4180" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2629" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="2561-2629" color="#ccffcc" type="standard" translated="1"/><Segment range="2630-3421" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="7" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-49" color="#ffff99" type="standard"/></Feature><Feature recentID="8" name="mCheryy" directionality="1" translationMW="25763.80" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="78-755" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MASSENVITEFMRFKVRMEGTVNGHEFEIEGEGEGRPYEGHNTVKLKVTKGGPLPFAWDILSPQFQYGSKVYVKHPADIPDYKKLSFPEGFKWERVMNFEDGGVATVTQDSSLQDGCFIYKVKFIGVNFPSDGPVMQKKTMGWEASTERLYPRDGVLKGETHKALKLKDGGHYLVEFKSIYMAKKPVQLPGYYYVDAKLDITSHNEDYTIVEQYERTEGRHHLFL*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  š<Notes>
<UUID>1cebd12e-8a18-4e13-8524-f88a6d9d87e6</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pPD9567-mCherry</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2016.6.20</Created>
<LastModified UTC="20:20:40">2025.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  P              E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..4710" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..4710" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
